Method of identifying the source of genetic information in dna
The present invention embeds predetermined information in the nucleotide sequence of DNA to identify the source of the genetic information in DNA. In particular, the pattern of a nucleotide sequence that normally does not appear in DNA is correlated with identification information for identifying a source of predetermined genetic information belonging to the DNA, and, in said portion of the DNA other than the gene, the nucleotide sequence that is correlated with the identification information is embedded in the DNA so as not to affect the genetic information in the DNA.
Publication number: US2002037521A1 | Search similar patents
A method for sustainable transgene transcription
The present invention relates to constructs and methods for improving expression of transgenes in plants, animals and humans by introducing introns into the transcript to limit the exon sizes to less than about 60 bp.
Publication number: WO2008138896A1 | Search similar patents
Efficient genetic suppressor elements
Genetic elements that are capable of inhibiting gene function are disclosed.
Publication number: EP1245673A2 | Search similar patents
Qtl mapping in plant breeding populations
This invention relates to a method for improving the efficacy of a plant breeding program by selectively altering the average of a quantitative phenotypic trait in a plant population. The method employs statistical models to predict the association of genetic markers with a desired phenotypic trait. These models allow the association to be extrapolated to the progeny of the plants tested as well as plants in other families within the breeding population. After the statistical association has been determined, the genetic markers which associate with quantitative trait loci can be used to screen for plants with the desired genetic markers to use as progenitors of an F1 seed population. Alternatively, after the alleles which associate with a QTL have been identified, the coding sequences of at least one of the alleles can be cloned and introduced into a plant to create a transgenic plant line.
Publication number: EP1042507A1 | Search similar patents
Process of producing environmentally safe transgenic organisms
A process of producing a transgenic multi-cellular plant or animal organism expressing a trait of interest and having a controlled distribution of said trait to progeny, wherein said process comprises hybridising a first multi-cellular organism or a cell thereof having a first heterologous DNA sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest and a second multi-cellular organism or a cell thereof having a second heterologous DNA sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, whereby said first and said second heterologous sequences are designed such that said trait of interest arises due to RNA trans-splicing after said hybridation.
Publication number: EP1499734A2 | Search similar patents
Method and apparatus for chemical genetic programming
A chemical genetic programming apparatus is provided, which enables programming by the application of a chemical genetic algorithm. A CPU 120 includes a tRNA transcripting unit 1201 performing transcription of tRNA from a second portion of DNA, an amino acid translating unit 1202 translating amino acids based on a third portion of DNA and an aminoacyl-tRNA table, an aminoacyl-tRNA updating unit 1203 updating the aminoacyl-tRNA table by a reaction of amino acids and tRNAs, and a phenotype tree generating unit 1205 for generating a phenotype tree by translation based on the aminoacyl-tRNA table and the first portion of DNA, and performs genetic operations on the DNA.
Publication number: US7610154B2 | Search similar patents
Gene expression or activity enhancing elements
The present invention relates to transgenic nucleic acids, expression cassettes, vectors, plant cells, plant organs and plants. The invention also relates to methods for increasing expression or activity of a target gene, particularly in a plant cell or plant organ, and also to uses of recombinant nucleic acids and expression cassettes to increase expression or activity of a target gene or for manufacturing of a vector, plant cell, plant organ or plant. Incidentally, the invention relates to enhancers for achieving increased expression or activity of a target gene, particularly in a plant cell or plant organ, when operably linked to a promoter functional in such plant cell, plant organ or plant. The invention is described herein with reference to the technical field of production of polyunsaturated fatty acids (PUFAs), without being limited to this technical field. For the production of desired molecules in plant cells, e.g. PUFAs, it is frequently required to express a target gene heterologous to the plant cell, or to overexpress a target gene naturally found in said plant cell.
Publication number: WO2015001505A2 | Search similar patents
Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes
This invention provides libraries of expression constructs having different untranslated regions (UTR) from a genome. The expression constructs include transcription regulatory sequences operably linked with a reporter gene and a 5′ UTR, a 3′ UTR or both, wherein the translation of the reporter gene is under the regulatory control of control regions in the UTR sequence. The libraries of this invention are useful for determining the impact of regulatory sequences in the UTRs on translation of open reading frames under a variety of conditions, such as different cellular environments.
Publication number: EP2135080A2 | Search similar patents
System and method to obtain oligo-peptides with specific high affinity to query proteins
The present invention relates to a method for constructing oligo-peptides with high binding affinity for a query protein.
Publication number: US2007015189A1 | Search similar patents
Es cell mutation method and system
This is intended to provide a technique for providing a stem cell having a mutation in both alleles (a pair of alleles). A method for producing a stem cell having a mutation in both chains of alleles which comprises: A) the step of providing a stem cell; B) the step of preventing Blm alleles from functioning in the stem cell; and C) the step of inducing mutation in the stem cell. It is also intended to provide a library of stem cells having a mutation in both chains of alleles wherein stem cells involved in the library have the mutation transferred thereinto over the entire genome.
Publication number: EP1757682A1 | Search similar patents
Broad-based disease association from a gene transcript test
System and method for preparing a blood sample for a disease association gene transcript test. Disease considerations for this unique test include a custom set of genetic sequences associated in peer-reviewed literature with various known diseases such as Addison's disease, anemia, asthma, atherosclerosis, autism, breast cancer, estrogen metabolism, Grave's disease, hormone replacement therapy, major histocompatibility complex (MHC) genes, longevity, lupus, multiple sclerosis, obesity, osteoarthritis, prostate cancer, and type 2 diabetes. The base dataset may be developed through clinical samples obtained by third-parties. Online access of real-time phenotype/genotype associative testing for physicians and patients may be promoted through a testing service.
Publication number: WO2008130416A1 | Search similar patents
A molecular vector identification system
The invention relates to a method for constructing a nucleic acid containing an identification insert, comprising providing a nucleic acid and an identification insert, wherein the identification insert is incorporated into the nucleic acid. The invention also relates to nucleic acids containing identification inserts.
Publication number: WO0214553A2 | Search similar patents
Prediction of disease-causing alleles from sequence context
An apparatus, system and method for predicting single nucleotide polymorphisms (SNPs) is disclosed. The present invention generally includes steps for obtaining a variation predictiveness matrix and predicting one or more single nucleotide variations of a nucleic acid sequence based on the variation predictiveness matrix. The variation predictiveness matrix may be made by calculating the variation frequency from a first base to a second base in a dataset of two or more bases and determining a variation predictiveness value from the calculated variation frequency.
Publication number: US2003138778A1 | Search similar patents
Method for the identification and isolation of strong bacterial promoters
The present invention relates to the identification and the isolation from bacterial genomes of new sequences having strong bacterial promoter activity. The invention also concerns new nucleic acids having strong bacterial promoter activity and their uses for improving RNA and/or protein synthesis using cellular (in vivo) or cell-free (in vitro) expression systems.
Publication number: EP1441036A1 | Search similar patents
Genome analysis method
This invention makes it possible to perform analysis for estimating the characteristics of a population using sample data. By obtaining sample data, embedding genetic (statistical) knowledge in a first and second state variable that have duality, and having the first and second state variables converge to the original value, the characteristics of the population of the sample data are estimated, and the estimated results of the characteristics of the population are output. By doing so, it is possible to perform analysis for estimating characteristics of a population using sample data.
Publication number: EP1832992A1 | Search similar patents