Apparatus and method for delivery of therapeutic and other types of agents
Implantable drug delivery systems target delivery of small volumes of drugs to specific tissues. In some cases, a drug delivery system includes an implantable osmotic pump connected to a drug-containing housing, with that housing connected to a needle, cochlear implant or other type of component for ultimate delivery to the target tissue. In some implementations, a subcutaneous port receives a fluid from an external pump. The port is connected to a needle or other component for delivery of one or more drugs to the target tissue. Both solid and liquid drug formulations can be used. In embodiments using solid drugs, a separate drug vehicle (such as saline) can be used to dissolve a portion of the solid drug, with the drug-loaded vehicle then delivered to the target tissue.
Publication number: US2007255237A1 | Search similar patents
Microneedle array patch
Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.
Publication number: EP1590034A1 | Search similar patents
Drug delivery apparatus
An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
Publication number: US2006030837A1 | Search similar patents
Fluidic pump and network system
Provided is a system capable of managing the delivery of a drug solution according to the therapeutic stage of the patient. The present invention is a fluidic pump (140) that delivers a drug solution to a patient and is capable of being connected to a network (170), the fluidic pump being provided with: a storage means for storing a clinical path; a means for receiving via the network (170) an identifier that represents the clinical path currently being used for the patient to whom a solution is to be delivered and information representing the current therapeutic stage of the patient to whom said solution is to be delivered in said clinical path; a means for acquiring, from the stored clinical path, the details of the medical action corresponding to the information representing the therapeutic stage, the details being contained in the clinical path specified by the identifier; a means for extracting information relating to the delivery of the drug solution, the information being contained in the acquired details of the medical action; and a means for controlling the fluidic pump on the basis of the extracted information relating to the delivery of the drug solution.
Publication number: WO2013128886A1 | Search similar patents
Implantable drug delivery system
A miniature implantable drug delivery capsule system. The drug delivery system (400) comprises one or more ball semiconductor aggregations (404) and (406) facilitating release of a drug stored in a reservoir (402). The first aggregate (404) is used for sensing and memory, and a second aggregation (406) for control aspects, such as for pumping and dispensing of the drug. Notably, the aggregates (404) and (406) may be interconnected by a common bus (410) for communication purposes, or may be implemented to operate independently of each other. Each aggregate (404) and (406) is encased in a semipermeable membrane (408) to allow species which are to be monitored, and drugs to be delivered, to freely diffuse. The system (400) may communicate with a remote control system, or operate independently on local power over a long period for delivery of the drug based upon a request of the patient, timed-release under control by the system (400), or delivery in accordance with measured markers.
Publication number: US6464687B1 | Search similar patents
Remote sensing and actuation of fluid of inner ear
A system for communicating with the inner ear is described. An acoustic transducer converts between electrical energy and mechanical energy. An inner ear catheter has a distal end in vibratory communication with the fluid of the inner ear, a proximal end in vibratory communication with the acoustic transducer, and a lumen filled with a catheter fluid for coupling vibratory signals between the distal end and the proximal end.
Publication number: US2008064918A1 | Search similar patents
Drug delivery with an expandable polymeric component
Embodiments are generally directed to the delivery of drugs through the use of an expandable polymeric component that is configured to swell when exposed to a recipient's bodily fluid. More specifically, in one embodiment an apparatus for implantation into a recipient comprises an expandable polymeric component and a drug delivery element that releasably carries a drug. The drug delivery element at least partially surrounds the expandable polymeric component.
Publication number: US2014276405A1 | Search similar patents
Implantable pump with adjustable flow rate
A valve (10) that is adapted to control the flow rate of fluid flow from an implantable pump or other fluid delivery device is provided. In general, the valve includes a multi-lumen member (12) that is adapted to receive fluid-flow therethrough, and a restrictor member (14) that is coupled to the multi-lumen member such that the restrictor member is effective to selectively restrict at least a portion of one or more lumens in the multi-lumen member to thereby adjust the flow rate of fluid flowing through the multi-lumen member. The valve can be built into an implantable drug pump to control fluid flow exiting the pump, or alternatively the valve can disposed within a catheter or otherwise coupled to an outlet port in an implantable drug pump to control the flow rate of fluid exiting the drug pump.
Publication number: EP1512422A1 | Search similar patents
The micro-needle (4) comprises a needle body with delivery means, a tip portion closing said delivery means and at least an opening (7,8) allowing a communication between said delivery means and the outside of the needle. Said delivery means comprise at least two inner independent lumens (5,6).
Publication number: EP2275164A1 | Search similar patents
Electromagnetically-actuated microfluidic flow regulators and related applications
A variable, closed-loop apparatus for regulating a microfluidic flow that employs a low-power deflection assembly, which is surface-mounted over a flexible membrane overlying a chamber integrated into a microfabricated platform. A flexible membrane, moveable between two positions, sealingly overlies the chamber. One of the positions of the membrane restricts the flow through the chamber to a greater degree than the other position. A deflection assembly disposed on the substrate over the membrane unidirectionally deflects the membrane, thereby regulating the flow through the chamber.
Publication number: US2005238506A1 | Search similar patents
Anchor for a sensor implanted in a bodily lumen
A device and method for centrally positioning a sensor (101) in a bodily lumen (102). A sensor support (103) is coupled to an anchor (100, 110) that is inserted into a bodily lumen (102). The anchor (100, 110) is then secured within the bodily lumen (102), in one embodiment, by attaching the support legs (104, 111, 112, 114) of the anchor (100, 110) to the bodily lumen (102). The support legs (104, 111, 112, 114) of the anchor (100, 110) have protrusions (105) to attach to the walls of the bodily lumen (102). The sensor (101) is positioned at the center of the lumen (102) to more accurately measure the physiological properties and biochemical parameters of the lumen (102). The anchor (100, 110) may be inserted during an intervention procedure or during a special insertion procedure. The sensor (101) may be remotely interrogated exterior to the bodily lumen (102) periodically or continuously. Furthermore, the sensor (101) may be provided with a protective coating to protect it from damage during insertion.
Publication number: EP1499234A1 | Search similar patents
System for delivery of therapeutic substances
A system and method for transitioning between therapeutic substances to be delivered at different flow rates to a patient. The first therapeutic substance is delivered to the patient at a known flow rate, a bridge duration equal to the known volume divided by the known flow rate is calculated; and the flow rate is controlled following introduction of a second therapeutic substance into the reservoir. If the second flow rate is lower than the first flow rate, delivery is begun of at least one of the first therapeutic substance and the second therapeutic substance at the second flow rate at least as soon as the bridge duration is over. If the second flow rate is higher than the first flow rate, delivery is begun of the at least one of the first therapeutic substance and the second therapeutic substance at the second flow rate at least as late as when the bridge duration is over.
Publication number: EP1490131A1 | Search similar patents