Cd-rom based optical biosensors
A CD-ROM based optical biosensor, system and method of sensing biological samples in the air includes treating the surface of a CD-ROM medium with a receptor capable of binding with a targeted biological sample. While continuous reading of the CD-ROM is conducted by a CD-ROM drive, an air-flow is directed through the CD-ROM drive, over and around the CD-ROM such that any targeted biological samples present in the air will bind with the receptors. The laser reader of the CD-ROM device detects these biological samples as they obstruct the data blocks present on the CD-ROM. A processor of the CD-ROM drive determines whether an output signal is required, and if so, appropriately sends one to an output device.
Publication number: US2006153015A1 | Search similar patents
High sensitivity biosensor using pixel analysis of cmos image sensor
The present invention relates to a method capable of dividing the surface of a measuring unit of a CMOS image sensor into a plurality of pixels, directly fixing a bioreceptor on the surface of the measuring unit of the CMOS image sensor, and measuring a chemical luminescence signal according to the density of a substance to be measured, so as to analyze the substance to be measured, and to a CMOS image sensor applied to same.
Publication number: WO2013147388A1 | Search similar patents
Biosensor and method for determining a toxin and uses for said biosensor
The invention relates to a biosensor for determining a toxin in a sample, with at least two enzymes arranged on the biosensor, which are brought into contact with a sample to be tested for the presence of at least one enzyme inhibitor, a measuring unit for measuring an enzyme inhibition, brought about by interaction between the enzymes on the biosensor and at least one inhibitor in the sample and an analytical unit for analysing the enzyme inhibition, wherein the analytical unit gives a relationship between the measured enzyme inhibitions and the toxicity of the sample to an organism. The invention further relates to a method for determining a toxin in a sample and inventive uses of said biosensor.
Publication number: WO2009153074A1 | Search similar patents
Ultra-sensitive detection of extremely low level biological analytes using electrochemical signal amplification and biosensor
This invention allows ultra-low levels of virtually any biological analyte to be detected and quantified rapidly, simply and inexpensively with an electrochemical biosensor using a novel electrochemical signal amplification technique. The invention amplifies detection signals from low level analytes using an innovative sandwich ELISA structure that replaces optical labels with a massive amount of electrochemically detectable guanine rich oligonucleotide tags. Selective binding is achieved with matched pairs of either commercial or custom analyte binding materials such as monoclonal antibodies or single stand DNA. The guanine tags are eluted from the sandwich structures and hybridize with complementary cytosine rich oligonucleotide recognition probes attached to the surface of a biosensor working electrode. An electrochemical technique generates a signal in proportion to the guanine level on the working electrode which is also proportional to the analyte level in the sample. Magnetic separation and a nanosensor are used to improve the signal-to-noise ratio for measuring analyte levels 1,000,000 times lower than enzyme-linked immunosorbent assay (ELISA).
Publication number: US2015141272A1 | Search similar patents
Input device, biosensor, program, computer-readable medium, and mode setting method
The purpose of the present invention is to provide an input device, a biosensor, a program, a computer-readable medium, and a mode setting method whereby an error in determination as to whether a mode of an object to be controlled is to be set can be decreased. An input device (100) is provided with: a sensor signal acquisition unit (101) that acquires a sensor signal; a waveform comparison unit (102) that compares waveforms of two or more time intervals of the sensor signal; and a mode setting unit (103) that sets a mode of a device (110) as the object to be controlled on the basis of a comparison result from the waveform comparison unit (102).
Publication number: WO2016009644A1 | Search similar patents
Biosensor, biosensor system and method of using thereof
A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.
Publication number: US2006205060A1 | Search similar patents
The present invention relates to an electron transport medium containing an osmium complex, which reacts with an enzyme capable of oxidizing and reducing a material to be analyzed, is not influenced by oxygen partial pressure, and stably maintains an oxidation-reduction form for a long time, to an oxidation-reduction reaction reagent, containing the osmium complex, for an electrochemical biosensor, and an electrochemical biosensor.
Publication number: WO2016108671A1 | Search similar patents
A biosensor according to one embodiment of the present invention is provided with: a substrate; and a sensor matrix that is present in a two-dimensional region on the substrate. The sensor matrix is provided with a plurality of base blocks. Each one of the plurality of base blocks is provided with at least three kinds of sensor elements.
Publication number: WO2016104517A1 | Search similar patents
A biosensor device (10) for detecting of molecules of an analyte in a sample (23) comprising: an identification element (18) comprising at least one self assembling monolayer (26) having a first surface, a transducer element (20) comprising a metal electrode (34) for receiving an electric signal from the reaction of the molecules in the sample with the at least one self assembling monolayer (26), and at least one electronic element (14, 16) for receiving the electric signal from the transducer element (20), for processing, and/or storing the electric signal. The at least one self-assembling monolayer (26) comprises at least one carboxylic acid-group for coupling the at least one self-assembling monolayer (26) to the surface (32) of the metal electrode (34).
Publication number: EP2016408A2 | Search similar patents
Methods for generating ph/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
Publication number: US2016025671A1 | Search similar patents
Biosensors, method of producing them and analysis methods using same
The invention concerns a biosensor comprising an enzymatic film and a transducer, characterised in that the film consists of a membrane with reagent groupings, at least one enzyme and two dialysis membranes. This biosensor has such stability that it can be used continuously for more than a month in an industrial analysing device mainly ensuring the regeneration of the biosensor and the dosing parameter measurement.
Publication number: WO9802569A1 | Search similar patents